A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4745 (2006.01) A61K 9/10 (2006.01) A61K 9/107 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 47/14 (2006.01) A61K 47/26 (2006.01) A61K 47/44 (2006.01)
Patent
CA 2612080
A pharmaceutical composition comprising a camptothecin as active ingredient is herein described. In particular immediate-release therapeutic systems are described for the improved oral absorption of 7-[(E)-t-butyloxyminomethyl] camptothecin, comprising a matrix consisting of liquid amphiphilic substances or having a melting point lower than 60~C, in which the active principle is at least partially dissolved and/or dispersed and/or inglobated.
La présente invention concerne une composition pharmaceutique dont le principe actif est la camptothécine. L'invention concerne plus particulièrement des systèmes thérapeutique offrant une meilleure absorption par voie orale de la 7-[(E)-t-butyloxyminométhyle] camptothécine. Ces systèmes comprennent une matrice constituée de substances liquides amphiphiles ou dont le point de fusion est inférieur à 60 °C, matrice dans laquelle le principe actif est au moins partiellement dissout, dispersé, et/ou englobé.
Longo Antonio
Pace Silvia
Pedrani Massimo
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a.
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