A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 27/34 (2006.01) A61L 27/26 (2006.01) A61L 27/44 (2006.01) A61L 27/52 (2006.01)
Patent
CA 2476656
The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.
L'invention porte sur un revêtement à base de matrices d'hydrogel bioactives stabilisées destinés à des substrats, tels les dispositifs médicaux. Cette invention concerne un substrat revêtu comprenant un substrat doté d'une surface, et une couche de matrice d'hydrogel bioactive recouvrant la surface du dispositif médical, cette matrice d'hydrogel comprenant un premier composant de masse moléculaire élevée et un second composant de masse moléculaire élevée, le premier et le second composants de masse moléculaire élevée étant chacun choisi dans le groupe polyglycanes et polypeptides, au moins un des premiers et seconds composants de masse moléculaire élevée étant immobilisé (par exemple par réticulation covalente) à la surface du substrat.
Hill Ronald Stewart
Klann Richard Chris
Lamberti Francis V.
Encelle Inc.
Sim & Mcburney
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