Immobilized cytokines

Details Immobilized cytokines Immobilized cytokines

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 9/16 (2006.01) A61K 38/19 (2006.01) A61K 47/48 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2047730

2047730 9009798 PCTABS00002 The present invention provides immobilized cytokines comprising cytokines bound to a solid, preferably biologically inert, support. The bound cytokine, for example IL-2, retains comparable biological activity when bound to the support. Accordingly, the bound cytokine is able to be utilized repeatedly and/or in significantly smaller quantities, as compared to an individual soluble cytokine. Cytokines of the present invention include, but are not limited to, IL-1-alpha, IL-1 beta, rIL-2, IL-2, IL-3, IL-4, IL-6, MuGMCSF, HuGMCSF, HuGCSF, HuEPO, alpha-interferon, gamma-interferon, TNF-alpha, HuILGF-I, HuILGF-II, FGFb, TGF-beta-II, HuEGF, HuPDGF.

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