Immobilized g-protein coupled receptors on liquid...

Details Immobilized g-protein coupled receptors on liquid... Immobilized g-protein coupled receptors on liquid...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) B01D 15/08 (2006.01) B01J 20/286 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) B01J 20/32 (2006.01)

Patent

CA 2412556

This invention provides an immobilized G-protein coupled receptor (GPCR) on a support in a liquid chromatography system. The method of the invention provides means of evaluating the attachment of an agent to a GPCR comprising the steps of (a) immobilizing a GPCR on an artificial membrane support in a column, (b) exposing the support with the GPCR to test the agent at varying concentrations in a liquid chromatography system, (c) eluting the test agent from the column, and (d) evaluating the elution profile of the test material from the column. Using this method, it is possible to evaluate the interaction of the test agent with the GPCR. Following elution, it is possible to directly determine molecular structure by passing the elute through other testing devices such as a mass spectrometer.

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