Immobilized labeling compounds and methods

Details Immobilized labeling compounds and methods Immobilized labeling compounds and methods

A - Human Necessities

61

K

A61K 51/08 (2006.01)

Patent

CA 2362860

The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to the support; and collecting the metal-conjugate complex released from the support. The metal catalyzes cleavage of the conjugate from the support upon complex formation resulting in a solutions substantially free of unlabeled conjugate.

L'invention concerne des méthodes et composés de marquage de conjugués avec des métaux, les méthodes consistant à coupler le conjugué avec une surface de support ; à introduire un métal complexant dans le support ; puis à collecter le complexe métal-conjugué libéré par le support. Le métal catalyse le clivage du conjugué avec le support par formation d'un complexe, ce qui produit une solution sensiblement exempte de conjugué non marqué.

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