Immobilized labelling method

Details Immobilized labelling method Immobilized labelling method

A - Human Necessities

61

K

A61K 51/08 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2175557

Described is a process for labelling ligands with metals comprising the steps of covalently coupling the ligand to a solid support via a metal-cleavablelinker, introducing a complex-forming metal to the support; and collecting the metal-ligand complex released from the support. The metal catalyzes cleavage of the ligand from the support upon complex formation resulting m a solution substantially free of unlabelled ligand.

Procédé de marquage de ligands avec des métaux, consistant tout d'abord à établir une liaison de covalence entre le ligand et un support solide au moyen d'un agent de liaison pouvant être scindé par un métal; puis à introduire sur le support un métal complexant et enfin à recueillir le complexe métal-ligand libéré par le support. Le métal catalyse la scission entre le ligand et le support en formant un complexe et permet d'obtenir ainsi une solution principalement exempte de ligand non marqué.

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