Immobilized probes and methods of detecting conformationally...

G - Physics – 01 – N

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G01N 33/483 (2006.01) C07K 1/32 (2006.01)

Patent

CA 2579848

The present invention provides methods of making immobilized probes that are specific for prion proteins, methods of using such probes to bind, detect, and remove prion proteins from samples, and kits for practicing the invention. The invention discloses immobilized probes that are locked into a particular, pre- determined configuration and that retain their activity and specificity even when exposed to conditions that would typically alter their activity and specificity.

La présente invention concerne des méthodes de préparation de sondes immobilisées qui sont spécifiques des protéines prions, des méthodes d'utilisation desdites sondes afin de lier, de détecter et d'éliminer des protéines prions d'échantillons, ainsi que des nécessaires pour la mise en pratique de l'invention. L'invention concerne des sondes immobilisées qui sont bloquées selon une configuration prédéterminée particulière et qui retiennent leur activité et leur spécificité même lorsqu'elles sont exposées à des conditions qui modifient généralement leur activité et leur spécificité.

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