C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07K 16/30 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2224797
The present invention relates to epithelial tumor cells with metastatic potential which have integrated in their genome or another replicative genetic element at least one externally introduced immortalizing oncogene and optionally at least one gene encoding an immunostimulatory factor which are expressed in such tumor cells. The invention further relates to antibodies which specifically recognize the epithelial tumor cells of the invention, to processes for the production of said tumor cells as well as pharmaceutical and diagnostic compositions comprising said tumor cells and antibodies, respectively. Finally the present invention relates to the use of the epithelial tumor cells and/or antibodies of the invention for the preparation of tumor vaccines and medicaments for the prophylaxis and/or treatment of cancer and/or the metastasis of cancer.
L'invention se rapporte à des cellules tumorales épithéliales ayant un potentiel métastatique qui ont intégré dans leur génome ou dans un autre élément génétique de répétition au moins un oncogène immortalisant introduit de façon externe et éventuellement au moins un gène codant un facteur immunostimulateur, qui sont exprimés dans de telles cellules tumorales. En outre, l'invention se rapporte à des anticorps reconnaissant spécifiquement les cellules tumorales épithéliales de cette invention, à des procédés pour la production desdites cellules tumorales ainsi qu'à des compositions pharmaceutiques et de diagnostic comportant respectivement lesdites cellules tumorales et lesdits anticorps. Enfin, l'invention décrit l'utilisation des cellules tumorales épithéliales et/ou anticorps pour la préparation de vaccins antitumoraux et de médicaments pour la prophylaxie et/ou le traitement du cancer et/ou de la métastase du cancer.
Dickmanns Achim
Fanning Ellen
Pantel Klaus
Riethmuller Gerhard
Mccarthy Tetrault Llp
Micromet Ag
Micromet Gmbh
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