Immortalized human cell lines containing exogenous...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 5/10 (2006.01) C12N 9/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2163233

Non-tumorigenic stable, human bronchial and liver epithelial cell lines are provided wherein the cell lines are capable of expressing human cytochrome P450 genes which have been inserted into the cell lines. Also provided am methods and kits for identifying potential mutagens, cytotoxins, carcinogens, chemotherapeutic and chemo-preventive agents utilizing these cell lines.

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