Immune activation by double-stranded polynucleotides

Details Immune activation by double-stranded polynucleotides Immune activation by double-stranded polynucleotides

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/071 (2010.01) C12N 5/078 (2010.01) C12N 15/117 (2010.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) C12N 15/00 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2309762

Double-stranded polynucleotide activates the expression of immune recognition molecules. The polynucleotide can have a minimal length and activates the expression of molecules not encoded by a nucleotide sequence that is not necessarily related to the polynucleotide. The present invention provides for a simple and specific system to activate expression of Class I and/or Class II molecules of the major histocompatibility complex (MHC), and allows regulation of expression of MHC molecules on the cell-surface of antigen presenting cells and other immune cells. Also provided are systems for the screening, identification, and isolation of compounds that increase or decrease this activation.

L'invention concerne un polynucléotide bicaténaire permettant d'activer l'expression des molécules de la reconnaissance immunitaire. Le polynucléotide de l'invention, qui peut être de longueur minimale, active l'expression de molécules non codées par une séquence nucléotidique qui n'est pas nécessairement associée au polynucléotide. La présente invention concerne un système simple et spécifique permettant d'activer l'expression des molécules de la classe I et/ou II du complexe majeur d'histocompatibilité, et de réguler l'expression de ces molécules à la surface des cellules porteuse d'antigènes et autres cellules immunitaires. L'invention concerne enfin des systèmes de criblage, d'identification et d'isolement de composés favorisant ou ralentissant cette activation.

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