Immune-modulating peptide

Details Immune-modulating peptide Immune-modulating peptide

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/10 (2006.01) C07K 5/107 (2006.01) C07K 5/11 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2446872

Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.

La présente invention concerne des peptides des SEQ ID NOs: 1 à 24 : qui induisent la production de superoxyde par les monocytes et neutrophiles humains ; qui induisent une augmentation du calcium intracellulaire produit par les monocytes ou neutrophiles du sang périphérique humain ; qui se lient au récepteur formyl peptidique (FPR) ou au récepteur 1 apparenté au récepteur formyl peptidique (FPRL1) ; qui induisent la migration chimiotactique des monocytes ou neutrophiles humains in vitro ; qui induisent la dégranulation des cellules exprimant le FPR ou des cellules exprimant le FPRL1 ; qui stimulent la phosphorylation d'une protéine-kinase régulée par signal extracellulaire via l'activation du FPR ou du FPRL1 ; ou qui stimulent la phosphorylation Akt via l'activation du FPR ou du FPRL1.

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