Immune privileged and modulatory progenitor cells

Details Immune privileged and modulatory progenitor cells Immune privileged and modulatory progenitor cells

A - Human Necessities

61

K

A61K 35/44 (2006.01) A61P 37/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2649874

Described herein is a method for modulating an immune reaction between lymphocytes and a body recognized by the lymphocytes as foreign. The method exploits the immunomodulating activity of a new class of progenitor cells termed HUCPVCs derived from the perivascular region of human umbilical cord. The method can also employ soluble factors exuded by cultured HUCPVCs. The method is useful to treat immune disorders including graft versus host disease, autoimmune disorders, and the like.

L'invention concerne un procédé permettant de moduler une réaction immunitaire entre des lymphocytes et un corps reconnu par les lymphocytes comme étranger. Le procédé exploite le processus d'immunomodulation d'une nouvelle classe de cellules progénitrices appelées HUCPVC issues de la région périvasculaire du cordon ombilical humain. Le procédé peut également employer des facteurs solubles exsudés par les HUCPVC cultivées. Le procédé est utile pour traiter des troubles immunitaires notamment la maladie du greffon contre l'hôte, des troubles auto-immuns et similaires.

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