Immune regulation based on the targeting of early activation...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2513905

Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods of use, are also disclosed.

L'invention concerne des méthodes permettant de traiter des sujets souffrant de troubles ou d'états caractérisés par une réponse immunitaire indésirable, qui consiste à administrer une quantité effficace d'un agoniste de molécule d'activation précoce, un antagoniste ou un agent de déplétion au sujet. L'invention concerne également des anticorps monoclonaux humains spécifiques des molécules d'activation précoce et des méthodes d'utilisation.

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