C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 21/00 (2006.01)
Patent
CA 2624755
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
L'invention concerne des oligonucléotides de régulation immune (IRO) utilisés comme antagonistes de TLR et des procédés d'utilisation de ceux-ci. Ces IRO possèdent des séquences uniques inhibant ou supprimant une signalisation induite par TLR, en réponse à un ligand TLR ou un agoniste TLR. Les procédés peuvent être utilisés dans la prévention et le traitement du cancer, d'un trouble auto-immun, d'une inflammation des voies aériennes, de troubles inflammatoires, d'une maladie infectieuse, de troubles de la peau, d'allergie, d'asthme ou d'une maladie causée par un pathogène.
Daqing Wang
Fugang Zhu
Kandimalla Ekambar R.
Lakshmi Bhagat
Li Yukui
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Idera Pharmaceuticals Inc.
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