Immune response modifier formulations and methods

Details Immune response modifier formulations and methods Immune response modifier formulations and methods

A - Human Necessities

61

K

A61K 31/4745 (2006.01) A61K 9/08 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2592575

An aqueous parenteral pharmaceutical formulation of the IRM drug compound N-[4- (4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-y1)butyl]methanesulfonamide dissolved in water, buffer selected from citric acid, acetic acid, lactic acid, succinic acid, and tartaric acid, and optionally a tonicity adjuster, preferably selected from sorbitol and mannitol, wherein the pH is no greater than 6 and the formulation is sterile and preferably substantially free of sodium chloride.

L'invention concerne une formulation pharmaceutique parentérale aqueuse qui comprend : un composé médicamenteux modificateur de réaction immunitaire N-[4-(4-amino-2-éthyl-1H-imidazo[4,5-c]quinolin-1-y1)butyl]méthanesulfonamide dissous dans de l'eau ; un tampon sélectionné parmi acide citrique, acide acétique, acide lactique, acide succinique, et acide tartarique ; et éventuellement un ajusteur de tonicité, de préférence sélectionné parmi sorbitol et mannitol. Ladite formulation présente un pH inférieur ou égal à 6, est stérile, et est sensiblement exempte de chlorure de sodium.

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