Immune response modulator alpha-2 macroglobulin complex

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 14/02 (2006.01) C07K 14/155 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2324864

Activation of .alpha.2-macroglobulin (.alpha.2M) with a nucleophilic compound followed by incubation of the activated .alpha.2M at elevated temperature with a biomolecule results in covalent incorporation of the intact biomolecule into the .alpha.2M molecule, without the use of proteinases. The thus-formed structurally defined and stable complex may be used as an antigen for stimulating the immune response, for example, in the form of a vaccine. Enhanced antigen presentation of a particular biomolecule is provided, especially for those that are poorly immunogenic; reduction of the immunodominance of particular epitopes is also provided.

L'activation de l'alpha-2 macroglobuline (.alpha.¿2?M) par un composé nucléophile, suivie de l'incubation à une température élevée de la .alpha.¿2?M activée avec une biomolécule entraîne l'incorporation covalente de la biomolécule intacte dans la molécule de .alpha.¿2?M, sans utilisation de protéinases. Le complexe structurellement stable et défini ainsi formé peut être utilisé comme antigène pour stimuler la réponse immunitaire, par exemple, sous la forme d'un vaccin. On obtient une meilleure présentation de l'antigène d'une biomolécule particulière, notamment pour celles qui sont faiblement immunogènes, et une réduction de l'immunodominance de certains épitopes.

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