C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/125, 167/129
C12N 9/10 (2006.01) A61K 38/45 (2006.01)
Patent
CA 1152000
CHL-40 PROCESS FOR PREPARING A PURIFIED IMMUNOGENIC GLUCOSYLTRANSFERASE ABSTRACT OF THE DISCLOSURE Immunization of animals with preparations containing more purified forms of glucosyltransferase (GTF) results in the presence of antibody in saliva demonstrable by functional inhibitions of enzyme activity and binding of radioactive enzyme. Serum antibody was also present. Immunized groups of animals had lower mean caries scores than comparably sham-immunized or nonimmunized control groups. Local immunization with GTF of serotype c or g or a Streptococcus mutans reduces the coloniza- tion, caries, and lesions caused by infection with S. mutans of serotype g (strain 6715) or c, or with serotype g or c, or with serotype a or g, respectively.
322048
Smith Daniel J.
Taubman Martin A.
Forsyth Dental Infirmary For Children
Seeman Dr. Carl von
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