Immunization by inoculation of dna transcription unit

Details Immunization by inoculation of dna transcription unit Immunization by inoculation of dna transcription unit

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 48/00 (2006.01) C07K 14/11 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2132836

This invention relates to a polynucleotide sequence consisting essentially of a DNA encoding a desired antigen operatively linked to a promoter region, and optionally one or more bacterial plasmid sequences, for use in vertebrate immunization. The uptake of the polynucleotide sequence by a host vertebrate results in the expression of the desired antigen or antigens, for example hemagglutinin, thereby eliciting humoral or cell-mediated immune responses or both. The elicited immune response can provide protection against infection by pathogenic agents, provide an anti-tumor response, or provide contraception. The host can be any vertebrate, avian or mammal, including humans.

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