A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/095 (2006.01) A61P 31/00 (2006.01)
Patent
CA 2530434
The present invention describes methods of immunizing a patient with a combined vaccine that offers protection against meningococcal disease caused by pathogenic bacteria Neisseria meningitidis serogroups A and C. The vaccine comprises at least two distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. The purified capsular polysaccharides of Neisseria meningitidis serogroups A and C are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long- lasting immunity to a variety ofN. meningitidis strains in infants.
La présente invention concerne des procédés d'immunisation d'un patient avec un vaccin combiné offrant une protection contre la maladie méningococcie due à la bactérie pathogène Neisseria meningitidis sérogroupes A et C. Ce vaccin comprend au moins deux conjugués distincts de protéine de polysaccharide qui sont formulés comme une dose unique de vaccin. Les polysaccharides capsulaires purifiés de Neisseria meningitidis sérogroupes A et C sont chimiquement activés et sélectivement fixés à un porteur à l'aide d'une liaison chimique covalente, ce qui donne des conjugués de protéine de polysaccharide permettant d'induire une immunité de longue durée à une variété de lignées de N. meningitidis chez les nourrissons.
Ryall Robert P.
Aventis Pasteur Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi Pasteur Inc.
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