Immunization of dairy cattle with chimeric gapc protein...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/09 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 15/62 (2006.01) C12N 15/70 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2411919

The recombinant production of Gap4, a chimeric GapC plasmin binding protein comprising the entire amino acid sequence of the Streptococcus dysgalactiae GapC protein in addition to unique amino acid sequences from the Streptococcus parauberis and Streptococcus agalactiae GapC proteins, is described. Also described is the use of Gap4 chimeric GapC protein in vaccine compositions to prevent or treat streptococcal infections in general and mastitis in particular.

L'invention concerne la production par recombinaison de Gap4, une protéine chimérique GapC liant la plasmine, contenant la séquence complète d'acides aminés de la protéine GapC Streptococcus dysgalactiae en plus des séquences d'acides aminés uniques des protéines GapC Streptococcus parauberis et Streptococcus agalactiae. L'invention concerne également l'utilisation de Gap4, protéine chimérique GapC, dans les compositions de vaccins destinés à la prévention ou au traitement d'infections streptococciques en général et de la mammite en particulier.

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