Immunization of infants

Details Immunization of infants Immunization of infants

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 39/00 (2006.01) A61P 37/04 (2006.01) C12N 15/85 (2006.01) C07K 14/005 (2006.01) C07K 14/195 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2272338

The present invention relates to methods and compositions which may be used to immunize infant mammals against a target antigen, wherein an immunogenically effective amount of a nucleic acid encoding a relevant epitope of a desired target antigen is administered to the infant. It is based, at least in part, on the discovery that such genetic immunization of infant mammals could give rise to effective cellular and humoral immune responses against target antigens.

L'invention concerne des compositions susceptibles d'être utilisés pour immuniser des nourrissons de mammifères contre un antigène cible et des procédés afférents; dans le procédé selon l'invention, une quantité efficace du point de vue immunogénique d'un acide nucléique codant un épitope approprié d'un antigène cible voulu est administrée au nourrisson. La présente invention se fonde, au moins en partie, sur la découverte qu'une telle immunisation génétique de nourrissons de mammifères pouvait provoquer des réponses immunitaires cellulaires et humorales effectives contre des antigènes cibles.

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