Immunizing against hiv infection

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/21 (2006.01) A61K 39/39 (2006.01) C07K 14/16 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2416725

A virus neutralizing level of antibodies to a primary HIV isolate is generated in a host by a prime-boost administration of antigents. The primary antigen is a DNA molecule encoding an envelop glycoprotein of a primary isolate of HIV-1 while the boosting antigen is either a non-infectious, non-replicating HIV- like particle having the envelope glycoprotein of a primary isolate of HIV-1 or an attenuated viral vector expressing an envelope glycoprotein of a primary isolate of HIV-1.

L'invention concerne un virus neutralisant le niveau des anticorps dans un isolat VIH primaire généré dans un hôte par l'administration d'antigènes donnant une première impulsion. L'antigène primaire est une molécule d'ADN codant une glycoprotéine enveloppe d'un isolat primaire de VIH-1, alors que l'antigène d'impulsion est soit une particule semblable au VIH non-répliquant, non-infectieux, possédant la glycoprotéine enveloppe d'un isolat primaire de VIH-1, soit un vecteur viral atténué, exprimant une glycoprotéine enveloppe d'un isolat primaire de VIH-1.

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