A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 38/04 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2477675
The present invention is directed to an immunizing composition containing an antigenic product such as a multiple antigen peptide system (MAPS) or a filamentous bacteriophage displaying an A.szlig.PP epitope spanning the .szlig.-secretase cleavage site of A.szlig.PP and a method for inducing an immune response against the .szlig.-secretase cleavage site of A.szlig.PP using this immunizing composition. The present invention is also directed to antibodies against the .szlig.-secretase cleavage site of A.szlig.PP and their use in a method for inhibiting the formation of amyloid .szlig..
L'invention porte sur une composition immunisante contenant un produit antigénique tel qu'un système multiple de peptides antigènes (MAPS) ou un bactériophage filamenteux présentant un épitope A.beta.PP qui répartit le site de clivage de .szlig.-sécrétase, et sur un procédé d'induction de réponse immunitaire contre le site de clivage de .szlig.-sécrétase de A.szlig.PP au moyen de cette composition immunisante. L'invention concerne aussi des anticorps contre le site de clivage de .szlig.-sécrétase de A.szlig.PP, ainsi que leur utilisation dans l'inhibition de la formation d'amyloïdes .szlig..
Borden Ladner Gervais Llp
Ramot At Tel-Aviv University Ltd.
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