C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/12 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2715033
The present specification discloses SNAP-25 compositions, methods of making .alpha.-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleavage site scissile bond from a SNAP-25 cleav-age product, .alpha.-SNAP-25 antibodies that bind an epitope comprising a carboxyl-terminus at the P1 residue from the BoNT/A cleav-age site scissile bond from a SNAP-25 cleavage product, methods of detecting BoNT/A activity, and methods of detecting neutral-izing .alpha.-BoNT/A antibodies.
La présente invention concerne des compositions de SNAP-25, des procédés de préparation danticorps a-SNAP-25 qui se lient à un épitope comprenant une terminaison carboxyle au résidu P1 de la liaison scissile du site de clivage BoNT/A dun produit de clivage SNAP-25, des anticorps a-SNAP-25 qui se lient à un épitope comprenant une terminaison carboxyle au résidu P1 de la liaison scissile du site de clivage BoNT/A dun produit de clivage SNAP-25, des procédés de détection de lactivité BoNT/A, et des procédés de détection de la neutralisation d'anticorps a-BoNT/A.
Aoki Kei Roger
Fernandez-Salas Ester
Garay Patton E.
Hodges D. Dianne
Wang Joanne
Allergan Inc.
Gowling Lafleur Henderson Llp
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