Immuno-based retargeted endopeptidase activity assays

Details Immuno-based retargeted endopeptidase activity assays Immuno-based retargeted endopeptidase activity assays

G - Physics

01

N

G01N 33/50 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2753894

The present specification discloses SNAP-25 immune response inducing compositions, methods of making .alpha.-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, a-SNAP-25 antibodies that selectively bind to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P1 residue of the BoNT/A cleavage site scissile bond, methods of detecting retargeted endopeptidase activity, and methods of detecting neutralizing a-re-targeted endopeptidase antibodies.

La présente invention concerne des compositions induisant une réaction immunitaire de la protéine SNAP-25, des procédés de production d'anticorps a-SNAP-25 qui se lient de manière sélective à un épitope comprenant une protéine SNAP-25 dotée d'une terminaison carboxyle sur le résidu P1 de la liaison scissile du site de coupure BoNT/A, des procédés de détection de l'activité des endopeptidases reciblées, et des procédés de détection de la neutralisation d'anticorps d'endopeptidases a-reciblées.

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