Immuno-interactive fragments of the .alpha.c subunit of inhibin

Details Immuno-interactive fragments of the .alpha.c subunit of inhibin Immuno-interactive fragments of the .alpha.c subunit of inhibin

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/10 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 5/00 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/575 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/74 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2387576

Novel immuno-interactive fragments of the .alpha.C portion of a mammalian inhibin .alpha.-subunit are disclosed, together with their variants and derivatives for producing antigen-binding molecules that are interactive with said .alpha.C portion, which are chemically well defined and which can be produced in commercially significant quantities. The antigen-binding molecules of the invention can be used for the detection of a mammalian inhibin and for the treatment and/or prevention of conditions associated with aberrant levels of a mammalian inhibin.

L'invention porte sur de nouveaux fragments immuno-interactifs de la portion .alpha.C de la sous-unité .alpha. de l'inhibine de mammifère, et sur leurs variantes et dérivés servant à la production de molécules de fixation d'antigènes interagissant avec ladite portion .alpha.C, et qui, bien définis chimiquement, peuvent être produits en quantités commerciales importantes. Lesdites molécules peuvent servir à la détection d'inhibines de mammifères et au traitement et à la prévention d'états associés à des niveaux aberrants d'inhibine de mammifère.

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