Immuno-modulatory composition

Details Immuno-modulatory composition Immuno-modulatory composition

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) A61P 37/00 (2006.01) A61P 37/02 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2740960

A composition for modulating the immune response in a mammal comprising a pharmaceutically acceptable carrier solution and a plurality of biodegradable nanoparticles, wherein the nanoparticles comprise a targeting moiety that is able to bind selectively to the surface of a T lymphocyte cell and/or of a vascular endothelial cell and wherein the nanoparticles further comprise leukaemia inhibitory factor (LIF). Nanoparticle-mediated targeted delivery of LIF can be used a means to guide tolerogenesis in a patient and has immediate clinical application for recipients of organ grafts and also for patients suffering from autoimmune disease.

La composition pour moduler la réponse immunitaire chez un mammifère selon l'invention comprend une solution de type véhicule pharmaceutiquement acceptable et une pluralité de nanoparticules biodégradables. Lesdites nanoparticules comprennent un fragment de ciblage, capable de se lier sélectivement à la surface d'un lymphocyte T et/ou d'une cellule endothéliale vasculaire, et comprennent, en outre, le facteur d'inhibition de la leucémie (LIF). La délivrance ciblée du facteur LIF médiée par les nanoparticules peut être utilisée comme moyen pour orienter la tolérogenèse chez un patient et a une application clinique immédiate pour les receveurs de greffes d'organes et également pour les patients atteints d'une maladie auto-immune.

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