Immuno-rna-constructs

Details Immuno-rna-constructs Immuno-rna-constructs

C - Chemistry, Metallurgy

12

N

C12N 15/113 (2010.01) A61K 31/7105 (2006.01) A61K 35/12 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C12N 15/11 (2006.01) C07H 21/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2633776

Subject of the invention is a compound, consisting of a targeting moiety which specifically binds to a disease related cell surface marker, a nucleic acid which specifically induces cell death and a linker, wherein the linker covalently links the targeting moiety to the nucleic acid. Subject of the invention are also medicaments comprising the compound and their use as a medicament for the treatment of diseases, including proliferative diseases.

L'invention se rapporte à un composé comprenant une fraction de ciblage qui se lie de manière spécifique à un marqueur de surface cellulaire dont la présence est liée à une maladie, un acide nucléique qui induit une mort cellulaire de manière spécifique, ainsi qu'un lieur. Selon l'invention, ce lieur établit une liaison covalente entre la fraction de ciblage et l'acide nucléique. Cette invention concerne en outre des médicaments qui comprenent ledit composé, ainsi que leur utilisation pour traiter des maladies parmi lesquelles figurent des maladies prolifératives.

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