A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 16/06 (2006.01) C07K 16/42 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2057860
An immunogen comprising a residue of a histamine-releasing peptide comprising a cationic N-terminal head and a hydrophobic C-terminal tail, together with a residue capable of eliciting antibodies against said peptide whilst inhibiting histamine release by said peptide is useful in anti-allergy treatment. Preferably the histamine-releasing peptide is of formula: Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, optionally amidated at the C terminal. Antibodies to the histamine-releasing peptide are useful for passive immunisation.
Un immunogène comprenant un résidu d'un peptide libérateur d'histamine comprenant une tête cationique à terminaison M et une queue hydrophobe à terminaison C, associé à un résidu capable de faire agir les anticorps contre ledit peptide tout en inhibant la libération d'histamine par ledit peptide est utile dans le traitement anti-allergique. De préférence, le peptide libérateur d'histamine correspond à la formule: Lys-Thr-Lys-Gly-Ser-Gly-Phe-Phe-Val-Phe, amidé ou non à la terminaison C. Les anticorps au peptide libérant de l'histamine sont utiles pour l'immunisation passive.
Jones Valerie
Lewin Ian V.
Nayyar Sarita
Stanworth Denis R.
British Technology Group Limited
Fetherstonhaugh & Co.
Peptide Therapeutics Limited
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