Immunoadhesin comprising a glycoprotein vi domain

Details Immunoadhesin comprising a glycoprotein vi domain Immunoadhesin comprising a glycoprotein vi domain

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) A61P 7/02 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2488630

The present invention provides a fusion protein comprising (a) the extracellular domain of glycoprotein VI or a variant thereof that is functional for binding to collagen and (b) the Fc domain of an immunoglobulin or a function-conservative part thereof, characterised by a polypeptide chain having an amino acid sequence as shown in Figure 7 and whereby the fusion protein is obtainable by a process which provides the fusion protein in the form of a specific dimer.

La présente invention concerne une protéine hybride comprenant (a) le domaine extracellulaire de la glycoprotéine VI ou d'un variant de cette dernière qui est fonctionnel pour se lier au collagène et (b) le domaine Fc d'une immunoglobuline ou d'une partie de conservation de la fonction de cette dernière, se caractérisant par une chaîne polypeptidique ayant une séquence d'acides aminés telle que présentée dans la figure 7, ladite protéine hybride pouvant être obtenue par un processus qui produit la protéine hybride sous forme d'un dimère spécifique.

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