Immunoadhesin for the prevention of rhinovirus infection

Details Immunoadhesin for the prevention of rhinovirus infection Immunoadhesin for the prevention of rhinovirus infection

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 38/00 (2006.01) C07K 14/095 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2407426

The immunoadhesions of the present invention are useful in treating rhinovirus infections. The immunoadhesions contain a chimeric ICAM molecule and may optionally also contain J chain and secretory compounds. The chimeric ICAM molecule is a fusion protein that has a rhinovirus receptor protein linked to an immunoglobulin protein. This invention also includes the greatly increased and improved method of producing immunoadhesions in plants. Each of the components of an immunoadhesin is produced in a plant cell and thereby assembles within the plant cell. This method of producing the immunoadhesions of the present invention results in the efficient and economic production of these molecules. The present invention also contemplates the production of immunoadhesions in a variety of eukaryotic cells including plants and mammalian cells. The immunoadhesions of the present invention are useful as a therapeutic against the common cold in humans which is caused by rhinoviruses.

Les immunoadhésines de l'invention sont utiles dans le traitement d'infections à rhinovirus. Les immunoadhésines contiennent une molécule-chimère ICAM et, éventuellement, également une chaîne J et des composés sécrétoires. La molécule-chimère ICAM est une protéine hybride qui présente une protéine réceptrice du rhinovirus liée à une protéine des immunoglobulines. L'invention concerne également la méthode considérablement améliorée de production d'immunoadhésines chez des plantes. Les constituants d'une immunoadhésine sont produits individuellement dans une cellule végétale à l'intérieur de laquelle ils forment des ensembles. Cette méthode de production d'immunoadhésines donne des rendements efficients et économiques de ces molécules. L'invention concerne en outre la production d'immunoadhésines dans diverses cellules eucaryotes, notamment dans des cellules végétales et mammifères. Les immunoadhésines de l'invention sont utiles comme agents thérapeutiques contre le rhume provoqué par des rhinovirus chez l'humain.

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