Immunoassay and method of use

C - Chemistry – Metallurgy – 12 – Q

Patent

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Details

C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/537 (2006.01) G01N 33/543 (2006.01) G01N 33/558 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2513579

A method for performing an immunoassay is described. The method is particularly useful for detecting extracellular polysaccharide (EPS) and/or lipopolysaccharide (LPS) producing microorganisms. The method is particularly useful for detecting microorganisms which produce extracellular polysaccharides (EPS) also known as exocellular polysaccharides, capsule, and/or lipopolysaccharides (LPS). In a preferred method for detecting microorganisms which produce EPS, LPS, or both, the EPS and/or LPS is extracted from a sample with cetyltrimethylammonium bromide (CTAB) to produce molecular aggregates which are then preferentially bound to colored polystyrene latex particles over other components in the sample, and the bound EPS and/or LPS detected using a lateral flow immunoassay apparatus' which has immobilized thereon antibodies specific for the--EPS and/or LPS. The method can also be used to detect particular viruses, for example viruses of the potyviridae or tobamoviridae group.

L'invention concerne un procédé permettant d'effectuer un dosage immunologique. Ce procédé convient en particulier pour la détection de micro-organismes producteurs de polysaccharides (EPS) extracellulaires et/ou de lipopolysaccharides (LPS). Il est particulièrement utile pour détecter des micro-organismes qui produisent des polysaccharides extracellulaires (EPS) également dénommés polysaccharides exocellulaires, capsules, et/ou lipopolysaccharides (LPS). Dans un mode de mise en oeuvre préféré, ce procédé de détection de micro-organismes producteurs de EPS et/ou de LPS, consiste à extraire les EPS et /ou les LPS d'un échantillon avec du bromure de cétylméthylammonium (CTAB) afin de produire des agrégats moléculaires qui se lient ensuite, d'une manière préférentielle par rapport aux autres composants de l'échantillon, avec des particules de latex polystyrène colorées, à détecter les EPS et/ou les LPS ainsi liés au moyen d'un appareil de dosage immunologique à flux latéral sur lequel sont fixés des anticorps spécifiques des EPS et/ou des LPS. Ce procédé peut également servir à détecter des virus particuliers, par exemples les virus des groupes potyviridae ou tobamoviridae.

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