Immunoassay for homocysteine

Details Immunoassay for homocysteine Immunoassay for homocysteine

G - Physics

01

N

G01N 33/577 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2188752

This invention pertains to methods to detect a compound in the presence of a homolog that is immunologically related to the analyte. The invention is particularly suited for the detection of homocysteine in the presence of cysteine. The methods of this invention involve chemically modifying both the analyte and the homolog to increase their immunogenicity and facilitate antibody recognition. More importantly, this modification is done to make these compounds immunologically distinct. Antibodies to the immunologically distinct compounds are then prepared. An assay protocol comprises chemically modifying the analyte and homolog and then immunochemically detecting the modified analyte by means of the aforementioned antibodies.

L'invention concerne des méthodes de détection d'un composé en présence d'un homologue associé immunologiquement à l'analyte. Elle porte, plus particulièrement, sur la détection de l'homocystéine en présence de cystéine. Lesdites méthodes consistent à modifier chimiquement à la fois l'analyte et l'homologue pour en augmenter l'immunogénicité et faciliter la reconnaissance des anticorps. Cette modification s'effectue, principalement, pour rendre ces composés distincts au plan immunologique. On prépare ensuite des anticorps dirigés contre les composés immunologiquement distincts. Un protocole de dosage consiste à modifier chimiquement l'analyte et l'homologue, et ensuite à détecter immunochimiquement l'analyte modifié au moyen des anticorps susmentionnés.

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