Immunoassay for non-a non-b hepatitis

Details Immunoassay for non-a non-b hepatitis Immunoassay for non-a non-b hepatitis

C - Chemistry, Metallurgy

07

K

C07K 14/18 (2006.01) G01N 33/576 (2006.01)

Patent

CA 2087974

2087974 9222571 PCTABS00018 An assay for antigens of hepatitis C virus utilizes a synthetic peptide comprising the first 38 amino acids of the capsid region containing at least two immunodominant epitopes. The assay detects antibodies in the sera of patients infected with the Non-A Non-B hepatitis virus. Of particular efficacy is a competitive inhibition assay, which incorporates in the liquid phase an inhibitor consisting of a peptide containing only one of the immunodominant capsid epitopes, which is capable of inhibiting binding of antibodies to all target epitopes present on the solid substrate.

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