Immunoassay for the measurement of collagen cleavage in...

Details Immunoassay for the measurement of collagen cleavage in... Immunoassay for the measurement of collagen cleavage in...

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) C07K 7/08 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) G01N 33/564 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2148132

2148132 9414070 PCTABS00032 A method for determining the degradation of cartilage in a biological sample is described. The method involves measuring the amount of unwound collagen present in a biological sample through the binding of unwound collagen with a monoclonal antibody. The monoclonal antibody selected for use in the method has the ability to bind to an epitope on unwound collagen chains or fragments of collagen containing this epitope. The monoclonal antibody is also characterized in that it does not bind to native helical collagen. The present invention also relates to a kit for the measurement of cartilage degradation.

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