Immunoassays for and monoclonal antibodies to prothrombin...

C - Chemistry – Metallurgy – 12 – P

Patent

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C12P 21/08 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) C12N 9/74 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2071211

Monoclonal antibodies and fragments thereof, with binding specificity for an epitope on the carboxy terminus of pro- thrombin activation peptides and prothrombin activation peptide degradation products, which can be used in immunoassays to predict thrombosis by measuring the extent of activation of prothrombin. These monoclonal antibodies are also included in a kit for performing such immunoassays.

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