Immunoassays for lamotrigine

G - Physics – 01 – N

Patent

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Details

G01N 33/53 (2006.01) C07K 1/10 (2006.01) C07K 16/00 (2006.01) G01N 37/00 (2006.01)

Patent

CA 2586511

Generally, the present invention relates to lamotrigine analogs that have substituents at the triazine 3-position and on the benzene 4-position and 5- position. The lamotrigine analogs can include immunogenic moieties that can be used to prepare anti-lamotrigine antibodies, or antigenic moieties that can be used in immunodiagnostic assays for lamotrigine. Also, the lamotrigine analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the lamotrigine analogs can be used in immunodiagnostic assays to compete with lamotrigine for binding with anti-lamotrigine antibodies.

De manière générale, cette invention se rapporte à des analogues de lamotrigine qui ont des substituants à la position 3 de la triazine et à la position 5 et 4 du benzène. Les analogues de lamotrigine peuvent comprendre des fractions immunogènes pouvant être utilisées pour préparer des anticorps anti-lamotrigine ou des fractions antigéniques pouvant être utilisées dans des dosages d'immunodiagnostic pour la lamotrigine. L'analogue de lamotrigine peut comprendre des fractions de marqueur servant à détecter la présence ou la quantité de l'analogue pendant un dosage d'immunodiagnostic. De plus, les analogues de lamotrigine peuvent être utilisés dans des dosages d'immunodiagnostic pour concurrencer la lamotrigine au niveau de la liaison avec des anticorps anti-lamotrigine.

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