G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2178504
The present invention relates to the field of cancer immunoassay. Specifically, a new immunoassay method for prostate specific antigen (PSA) is presented. Also presented is a complex which resembles a complex of PSA and .alpha.-antichymotrypsin (ACT) that can be used as a calibrator or control in an immunoassay for PSA. Further presented is a method for fractionating polyclonal antibodies, to PSA, into those which bind epitopes that are masked by the binding of PSA to ACT and those which do not bind such epitopes.
La présente invention concerne un immunodosage auquel on fait appel en cancérologie. De façon spécifique, un nouveau procédé d'immunodosage relatif à l'antigène spécifique de la prostate (PSA) est décrit. L'invention concerne également un complexe qui ressemble au complexe PSA et .alpha.-antichymotrypsine (ACT) qui peut être utilisé comme élément d'étalonnage ou témoin dans un immunodosage relatif au PSA. Est également décrit un procédé permettant de séparer, parmi des anticorps polyclonaux dirigés contre le PSA, ceux qui fixent des épitopes qui sont masqués par la liaison du PSA à l'ACT de ceux qui ne fixent pas de tels épitopes.
Alexander Debra B.
Dowell Barry L.
King Carol A.
O'morchoe Susan B.
Smith Allan H.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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