Immunoassays for topiramate

Details Immunoassays for topiramate Immunoassays for topiramate

G - Physics

01

N

G01N 33/53 (2006.01) C07K 1/10 (2006.01) C07K 1/13 (2006.01) C07K 16/00 (2006.01) C12P 7/00 (2006.01) G01N 33/532 (2006.01) G01N 33/533 (2006.01) G01N 33/534 (2006.01) G01N 33/546 (2006.01)

Patent

CA 2586506

Generally, the present invention relates to topiramate analogs that have substituents at the sulfamate group or at the 9-position or 10-position. The topiramate analogs can include immunogenic moieties that can be used to prepare anti-topiramate antibodies, or antigenic moieties that can be used in immunodiagnostic assays for topiramate. Also, the topiramate analog can include tracer moieties for detecting the presence or amount of the analog during an immunodiagnostic assay. Additionally, the topiramate analogs can be used in immunodiagnostic assays to compete with topiramate for binding with anti-topiramate antibodies.

De manière générale, la présente invention concerne des analogues de topiramate qui ont des substituants au niveau du groupe sulfamate ou à la position 9 ou 10. Les analogues de topiramate peuvent comprendre des fractions immunogènes pouvant être utilisées pour préparer des anticorps anti-topiramate ou des fractions antigéniques pouvant être utilisées dans des dosages d'immunodiagnostic pour le topiramate. L'analogue de topiramate peut également comprendre des fractions traceur qui servent à détecter la présence ou la quantité de l'analogue au cours d'un dosage d'immunodiagnostic. De plus, les analogues de topiramate peuvent être utilisés dans des dosages d'immunodiagnostic pour concurrencer le topiramate au niveau de la liaison avec les anticorps anti-topiramate.

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