Immunoconjugate

Details Immunoconjugate Immunoconjugate

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2120023

-22- ABSTRACT OF THE DISCLOSURE An immunoconjugate which is not cleaved and is stable in the body, and which has a strong pharmacological effect is disclosed. The immunoconjugate according to the present invention comprises an antibody or an antigen-binding fragment thereof and abrin A chain, said antibody or antigen-binding fragment thereof and said abrin A chain being bonded to a cross-linking agent via thioether bonds, respectively, which cross-linking agent is not cleaved in the body.

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