Immunoconjugates

Details Immunoconjugates Immunoconjugates

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12N 15/09 (2006.01) C12N 15/64 (2006.01) C12N 15/70 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12N 15/13 (2006.01) C12N 15/19 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2138928

The present invention relates to new fusion proteins which consist of a tumor-associated targeting element preferentially a monoclonal antibody or a fragment thereof recognizing a molecule which is preferentially expressed on human tumor cells such as the human epidermal growth factor receptor (EGFR), and a biologically active ligand such as a growth and/or differentiation factor. The resulting fusion protein may be used to deliver the biologically active ligand to a specific target cell or tissue. The new immunoconjugates can be used in tumor therapy.

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