Immunoconjugates and methods for their use in tumor therapy

Details Immunoconjugates and methods for their use in tumor therapy Immunoconjugates and methods for their use in tumor therapy

A - Human Necessities

61

K

167/129

A61K 39/385 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1304293

Abstract Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid, Rep- resentative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells. 149Z0531D7.9

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