C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/100, 260/110
C07D 501/00 (2006.01) A61K 47/48 (2006.01) C07D 463/00 (2006.01) C07D 498/04 (2006.01) C07D 499/00 (2006.01) C07D 519/00 (2006.01) C12N 9/78 (2006.01)
Patent
CA 2030564
2030564 9011782 PCTABS00002 A drug delivery system is described in which an immunoconjugate and a prodrug are used in association with each other to deliver a drug to a host target site such as a tumour. The immunoconjugate comprises an antibody or antibody fragment to which is attached a .beta.-lactamase or an active fragment thereof. The prodrug is a cyclic amide derivative of a drug or an unstable precursor thereof in which the drug or precursor is attached to the remainder of the prodrug such that it forms a leaving group which on hydrolysis of the prodrug is eliminated as the active drug or unstable precursor. Particular prodrugs include penicillin or cephalosporin derivatives and other .beta.-lactams to which are attached any physiologically active substances, particularly antineoplastic agents, antiviral, antibacterial or antifungal compounds. In use the immunoconjugate is administered first such that it localises at the host target site. Subsequent administration of the prodrug results in .beta.-lactamase catalysed hydrolysis of the prodrug at the target site with release of the active drug or unstable precursor.
Alexander Rikki Peter
Eaton Michael Anthony William
Pratt Andrew John
Celltech Therapeutics Limited
Kirby Eades Gale Baker
LandOfFree
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