C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) C07K 1/13 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2218898
Disclosed are polynucleotides encoding single chain variable region fragments of a monoclonal antibody to CD19 and methods for preparing the same. Also disclosed are single chain variable region polypeptides, methods for preparing the same, point modified polypeptides, and dimers derived therefrom. An additional aspect of the invention discloses immunoconjugates formed between a polypeptide of the invention and cytotoxic agents, as well as methods for their preparation, as well as use in the treatment of cancer.
L'invention se rapporte à des polynucléotides codant des fragments monocaténaires de régions variables d'un anticorps monoclonal contre CD19 et à leurs procédés de préparation. L'invention se rapporte également à des polypeptides monocaténaires de régions variables, à leurs procédés de préparation, à des polypeptides modifiés en certains sites et à des dimères dérivés de ceux-ci. Un autre aspect de l'invention concerne des immunoconjugués formés entre un polypeptide de l'invention et des agents cytotoxiques, leurs procédés de préparation et leur utilisation dans le traitement du cancer.
Bejcek Bruce E.
Kersey John H. Jr.
Uckun Fatih M.
Wang Duo
Robic
The Regents Of The University Of Minnesota
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