Immunoconjugates with an intracellularly-cleavable linkage

Details Immunoconjugates with an intracellularly-cleavable linkage Immunoconjugates with an intracellularly-cleavable linkage

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2749501

The present invention relates to therapeutic conjugates with improved ability to target various diseased cells con-taining a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to pro-cesses for making and using the conjugates.

La présente invention porte sur des conjugués thérapeutiques à capacité améliorée destinés à cibler diverses cellules malades contenant une fraction de ciblage (telle qu'un anticorps ou un fragment d'anticorps), un liant et une fraction thérapeutique, et porte en outre sur des procédés de fabrication et d'utilisation des conjugués.

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