Immunocontraceptive compositions containing sperm antigens,...

Details Immunocontraceptive compositions containing sperm antigens,... Immunocontraceptive compositions containing sperm antigens,...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A23K 1/16 (2006.01) A61K 39/385 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/554 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2259147

The invention relates generally to immunocontraceptive vaccine compositions comprising antigenic polypeptides having mammalian sp56 sperm protein antigenic determinants. The antigenic polypeptides can be synthetic polypeptides, fusion proteins and chimeric molecules. The vaccine is preferably administered to feral mammals in bait or feed formulations. Certain embodiments describe the use of species specific sequences of sp56. Also described are immunocontraceptive methods, antibodies immunoreactive with the sp56 antigenic determinants, and methods for screening for sperm fertility.

L'invention concerne en général des compositions de vaccin immunocontraceptif, comprenant des polypeptides antigéniques contenant des déterminants antigéniques de protéine mammalienne de sperme sp56. Les polypeptides antigéniques peuvent être des polypeptides synthétiques, des protéines hybrides et des molécules chimères. Le vaccin est administré de préférence à des mammifères sauvages sous forme d'appât ou d'aliment pour animaux, Cerains modes de réalisation décrivent l'utilisation de séquences de sp56 spécifiques aux espèces. L'invention concerne également des procédés immunocontraceptifs, des anticorps immunoréactifs avec les déterminants antigéniques sp56, et les procédés de criblage pour la fertitité du sperme.

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