Immunocytokines for tumour therapy with chemotherapeutic agents

A - Human Necessities – 61 – K

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Details

A61K 45/06 (2006.01) A61K 31/4188 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2747154

Immunocytokine comprising cytokine, e.g. interleukin 2(IL-2), conjugated to antibody against tumour neovasculature antigen, e.g. tenascin-C, for use in combination therapy with chemotherapeutic agent such as temozolomide. Use of immunocytokine and chemotherapy for treatment of tumours e.g. glioblastoma and other cancers.

L'invention porte sur une immunocytokine qui comporte une cytokine, par exemple l'interleukine 2 (IL-2), conjuguée à un anticorps dirigé contre un antigène de néo-vascularisation tumorale, par exemple la ténascine-C, pour une utilisation dans une thérapie de combinaison avec un agent chimiothérapique tel que le témozolomide. L'invention porte également sur une utilisation de l'immunocytokine et sur une chimiothérapie pour le traitement de tumeurs, par exemple un glioblastome et d'autres cancers.

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