Immunodiagnostic assay for rheumatoid arthritis

Details Immunodiagnostic assay for rheumatoid arthritis Immunodiagnostic assay for rheumatoid arthritis

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 16/18 (2006.01) C07K 16/38 (2006.01) C07K 16/42 (2006.01) C07K 19/00 (2006.01) G01N 33/564 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2082529

2082529 9119001 PCTABS00008 The assay of rheumatoid arthritis by reference to IgA-.alpha.1-antitrypsin complex present in analytes is facilitated by certain novel antibody reagents. These are ligands comprising an antibody domain specific for an antigenic determinant of a complex of human IgA and .alpha.1-antitrypsin, said antibody domain being substantially non reactive with free human IgA and free human .alpha.1-antitrypsin. Monoclonal antibodies to the naturally occurring IgA-.alpha.1AT complex and monoclonal or polyclonal antibodies to a synthetic peptide are preferred. The synthetic peptide in itself part of the invention and preferably has an amino acid sequence: Val-Ser-Val-Val-Met-Ala-Glu-Val-Asp-Gly-Thr-Cvs-Tvr.

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