Immunodominant acetylcholine receptor peptides useful for...

Details Immunodominant acetylcholine receptor peptides useful for... Immunodominant acetylcholine receptor peptides useful for...

C - Chemistry, Metallurgy

12

N

195/34.7

C12N 5/08 (2006.01) C07K 14/705 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2036733

The present invention provides an in vitro enriched population of T-helper (TH) cells having a receptor site for at least one synthetic peptide corresponding to sequences found in the a- subunit of the nicotinic acetyl choline receptor (AChR), which synthetic peptide has the formula: gln-ile-val-thr-thr-asn-val-arg-leu-lys-gln-gln-trp-val-asp- tyr-asn-leu-lys-trp; ala-ile-val-lys-phe-thr-lys-val-leu-leu-gln-tyr-thr-gly-his- ile-thr-trp-thr-pro; ser-thr-his-val-met-pro-asn-trp-val-arg-lys-val-phe-ile-asp- thr-ile-pro-asn; ile-ile-gly-thr-leu-ala-val-phe-ala-gly-arg-leu-ile-glu-leu- asn-gln-gln-gly; or a fragment of one of said peptides having at least five amino acid residues.

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