Immunoenhancer-linked oligomeric hiv vaccines

Details Immunoenhancer-linked oligomeric hiv vaccines Immunoenhancer-linked oligomeric hiv vaccines

A - Human Necessities

61

K

A61K 39/21 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2739288

Provided herein are immunogenic compositions comprising fusion proteins, the fusion proteins comprising lentivirus gp41 or a fragment thereof, a trimerization or oligomerization motif and an immunoenhancer that elicit potent and broad HIV neutralizing antibody responses in the immunized hosts. Also disclosed are methods of making and using the immunogenic compositions.

L'invention porte sur des compositions immunogènes qui comportent des protéines hybrides, les protéines hybrides comportant le gp41 de lentivirus ou un fragment de celui-ci, un motif de trimérisation ou d'oligomérisation et un stimulateur d'immunité qui déclenchent de fortes  réponses puissantes d'anticorps neutralisant le VIH chez les hôtes immunisés. L'invention porte également sur des procédés de fabrication et d'utilisation des compositions immunogènes.

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